My latest Skyrim mod is up. Introducing QuickDrop! It lets you bind hotkeys to quickly keep or drop the last few items you picked up without ever having to open your inventory.
Were you trying to pick up a soulgem, but you accidentally picked up a piece of random dungeon clutter, instead? Rather than wasting time dicking around in your inventory trying to find it and drop it, tap the hotkey to spit it right back up!